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Obesity

A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

Locations

Australia, United Kingdom, United States

Start date

08/01/2026

Identifiers

Trial ID NN9838-4968,
NCT number NCT07253285,
Eudract number Not Available

Summary

This study will look at how well CagriSema and cagrilintide help children and adolescents with excess body weight lose weight. The study has 2 parts: main and extension study. In the main study, participants will either get CagriSema (a new study drug), cagrilintide (a new study drug), semaglutide (a drug that doctors can already prescribe to adolescents and adults) or placebo (a placebo looks like the treatment being tested, but doesn't have any active ingredients in it). Which treatment participants will get is decided by chance. Participants who get semaglutide in the main study will not take part in the extension study. If participants take part in the extension study, they will get either CagriSema or cagrilintide in this part of the study. Like all drugs, the study drugs may have side effects. The total time participants will be in the main study is about 1 year and 6 months. If participants take part in the extension study, the total time is about 4 years and 10 months.

Trial Overview:

Condition

Overweight

Obesity

Treatment

DRUG: Cagrilintide

DRUG: Semaglutide

DRUG: Placebo cagrilintide

DRUG: Placebo semaglutide

Study type

INTERVENTIONAL

Trial duration

Jan 08 2026 - Sep 20 2033

Participants

460

Phase

III

Are you eligible?

Gender

Male and female

Age

8 to 18 years old

Questions or concerns

Do you have any question about what it’s like being a clinical volunteer? Have a look at our answers to frequently asked questions.

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