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Healthy Other

A Research Study Looking at How a Single Dose of the Study Medicine NNC0194-0499 Behaves in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function

Locations

Not recruiting

Start date

05/07/2023

Identifiers

Trial ID NN9500-4621,
NCT number NCT05917938,
Eudract number 2022-001835-10

Summary

The study medicine NNC0194-0499 is under development for non-alcoholic fatty liver disease (NAFLD) including non-alcoholic steatohepatitis (NASH). All participants will receive a single dose of 30 milligram (mg) of the study medicine. The study medicine will be given in the form of an injection of 0.6 millilitres in a skinfold of the thigh (subcutaneous). The study will last for up to 64 days. Women cannot take part if pregnant, breast-feeding or plan to get pregnant during the study period. Women who are able to become pregnant must use highly effective contraception and will be counselled on the use of contraception. Participants with impaired liver function will undergo an ultrasound of the belly and measurement of brain activity.

Trial Overview:

Condition

Hepatic Impairment

Healthy Volunteers

Treatment

DRUG: NNC0194-0499

Study type

INTERVENTIONAL

Trial duration

Jul 05 2023 - Jan 30 2025

Participants

35

Phase

I

Are you eligible?

Gender

Male and female

Age

18 to 80 years old

Questions or concerns

Do you have any question about what it’s like being a clinical volunteer? Have a look at our answers to frequently asked questions.

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