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Cardiovascular disease Diabetes

AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications

Locations

United States

Start date

24/08/2026

Identifiers

Trial ID NN9490-8665,
NCT number NCT07797335,
Eudract number Not Available

Summary

This study is being conducted to find out how well zenagamtide works and how safe it is compared to insulin glargine in participants with type 2 diabetes who are at higher risk of heart and blood vessel problems and are already taking 1 to 3 diabetes medications. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get zenagamtide, (the treatment being tested) or insulin glargine (a comparator) and which treatment participants get is decided by chance.

Trial Overview:

Condition

Type 2 Diabetes

Cardiovascular Risk

Treatment

DRUG: Zenagamtide

DRUG: Insulin glargine U-100

Study type

INTERVENTIONAL

Trial duration

Aug 24 2026 - Sep 20 2028

Participants

1778

Phase

III

Are you eligible?

true

Gender

Male and female
true

Age

45 years and older

Find out how you can participate

Questions or concerns

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