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Obesity Other

AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea

Locations

Australia, China, Germany, India, Japan, Poland, Spain, Taiwan, Turkey (Türkiye), United States

Start date

05/05/2026

Identifiers

Trial ID NN9490-8293,
NCT number NCT07571109,
Eudract number Not Available

Summary

This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.

Trial Overview:

Condition

Obesity

Overweight

Obstructive Sleep Apnoea

Treatment

DRUG: NNC0487-0111

DRUG: Placebo (matched to NNC0487-0111)

Study type

INTERVENTIONAL

Trial duration

May 05 2026 - Aug 21 2028

Participants

300

Phase

III

Are you eligible?

true

Gender

Male and female
true

Age

18 years and older

Find out how you can participate

Questions or concerns

Do you have any question about what it’s like being a clinical volunteer? Have a look at our answers to frequently asked questions.

This site contains information about clinical trials sponsored by Novo Nordisk. It is not intended to replace the advice of a healthcare professional and should not be construed as providing advice or making a recommendation. The information on this site should not be relied on as the basis for any decision or action. Only a physician can determine whether a specific product is correct for a particular patient. If you have questions regarding any information contained on this site you should consult a physician.