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Obesity

AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

Locations

United States

Start date

24/02/2026

Identifiers

Trial ID NN9490-8021,
NCT number NCT07339423,
Eudract number Not Available

Summary

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Trial Overview:

Condition

Obesity

Treatment

DRUG: NNC0487-0111

DRUG: Placebo (matched to NNC0487-0111)

Study type

INTERVENTIONAL

Trial duration

Feb 24 2026 - Aug 21 2029

Participants

1150

Phase

III

Are you eligible?

Gender

Male and female

Age

18 years and older

Questions or concerns

Do you have any question about what it’s like being a clinical volunteer? Have a look at our answers to frequently asked questions.

This site contains information about clinical trials sponsored by Novo Nordisk. It is not intended to replace the advice of a healthcare professional and should not be construed as providing advice or making a recommendation. The information on this site should not be relied on as the basis for any decision or action. Only a physician can determine whether a specific product is correct for a particular patient. If you have questions regarding any information contained on this site you should consult a physician.