Condition
Healthy Volunteers Sickle Cell Disease, Thalassemia
The study aims to test if a new medicine called etavopivat potentially affects other medicines in healthy participants. The purpose of the study is to investigate whether the use of etavopivat affects the breakdown and metabolism of commonly used medicines in the body. During the study, participants will receive etavopivat and five different medicines that are already approved and available on the market, and which can be prescribed by doctors. These marketed medicines are called substrate drugs and they are: digoxin, pitavastatin, metformin, midazolam, and rosuvastatin. During a period of the study, participants will take 2 tablets of etavopivat daily for 10 consecutive days. The study will last for about 34 to 64 days.
Healthy Volunteers Sickle Cell Disease, Thalassemia
DRUG: Etavopivat
DRUG: Digoxin
DRUG: Pitavastatin
DRUG: Metformin
DRUG: Midazolam
DRUG: Rosuvastatin
Do you have any question about what it’s like being a clinical volunteer? Have a look at our answers to frequently asked questions.
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